June 7, 2018
U91快色 researchers make breakthrough in understanding of inflammatory bowel disease
Andre Buret says he and partner John Wallace are on the path to a new drug that will help treat IBD.
Riley Brandt, 91快色
Living with chronic inflammatory bowel diseases (IBD) such as Crohn鈥檚 disease or ulcerative colitis can be agonizing, requiring drastic lifestyle changes and expensive drug treatments. There鈥檚 no cure for Crohn鈥檚 and only surgery can eliminate ulcerative colitis, but 91快色 researchers have made a discovery, published this month in the journal, that could lead to an effective drug treatment for these diseases 鈥 and potentially open up new therapies for a wide range of conditions connected to disruptions in the gut microbiome.
鈥淲e are now on the path towards a new drug that will help treat these diseases,鈥 says Dr. Andre Buret, PhD. 鈥淔or patients with IBD, this is extremely exciting because it may open up revolutionary treatment options.鈥
Buret鈥檚 team, including his research partner Dr. John Wallace, PhD, with the , have identified a key mechanism underlying the ability of certain intestinal bacteria to contribute to the ulceration and inflammation that is characteristic of Crohn鈥檚 disease and ulcerative colitis. Moreover, they鈥檝e discovered that hydrogen sulfide-releasing drugs can reverse these effects, leading to resolution of the inflammation and healing of intestinal ulcers.
The researchers observed that in IBD patients, healthy bacteria had found a way to escape the microbiome film that lines everyone鈥檚 intestines and turn virulent by accessing excess iron in the gut. By using a hydrogen sulfide-releasing drug to 鈥渕op up鈥 the excess iron, they were able to reverse the process. These laboratory studies were performed using tissues from healthy volunteers and from IBD patients. This novel drug is being developed by the company created from their discoveries, Antibe Therapeutics Inc.
Symptoms can manifest in a variety of ways in IBD patients and current treatments involve a host of anti-inflammatories and steroids which can have serious side effects. Some are also very costly and require intravenous infusions.
鈥淭his will be an inexpensive alternative drug, which can be taken orally,鈥 says Buret, a professor in the Department of Biological Sciences and associate vice-president (research).
The next step will be for human trials to test how effective the treatment will be on IBD patients. Buret and Wallace will work with U91快色鈥檚 to further evaluate their findings and move forward on the research.
Buret believes microbiome researchers will be keen to explore new lines of inquiry this research has opened up.
鈥淚t鈥檚 been shown that the gut microbiome plays a critical role to maintain our overall health,鈥 says Buret. 鈥淚f there are disruptions in the microbiome, research has shown it can cause a number of disorders, not just in the intestine. It goes beyond the intestine. It鈥檚 been implicated in arthritis, brain disorders and obesity.
鈥淢ore studies still need to be done but it鈥檚 really exciting to ask these questions. It has huge potential.鈥
The lab studies for the new paper were performed by Dr. Jean-Paul Motta, PhD, a postdoctoral fellow sponsored by Eyes High and Alberta Innovates fellowships. The research was supported by grants from Crohn鈥檚 Colitis Canada, the Canadian Institutes of Health Research, and the National Science and Engineering Research Council of Canada.
Andre Buret is a member of the Inflammation Research Network, the Snyder Institute for Chronic Diseases at the Cumming School of Medicine, and the Host-Parasite Interactions Program. John Wallace is an adjunct professor in the Department of Physiology and Pharmacology and an associate member of the Inflammation Research Network at the Cumming School of Medicine.